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PrecisionSurgeryME

University College London

Department of Surgical Biotechnology

Research & Academic Work

Advancing Colorectal Care Through Research

Alongside his surgical practice, Mr Eddama is a Principal Research Fellow at University College London, where he leads a translational research programme spanning extracellular vesicle diagnostics, epigenetic therapies in inflammatory bowel disease and research embedded in everyday NHS practice.

PI-led research funding secured
£400k+
Granted 2024 for a colorectal cancer screening method
Patent
PhD students supervised (3 graduated)
6
H-index
9

University College London

Mr Eddama completed his PhD at UCL in 2017, on the angiogenic characterisation of the mesenteric adipose tissue in Crohn’s disease. He has held academic appointments at UCL since 2016 and is now a Principal Research Fellow, Principal Investigator on two research projects and supervisor to PhD students. He also directs the “Doctor as Data Scientist” module at UCL Medical School.

UCL Profiles page(opens in a new tab)

Research interests

Themes across his published work

  • Extracellular vesicle diagnostics

    Blood-based biomarkers carried in extracellular vesicles, with the aim of earlier and less invasive detection of colorectal and other cancers.

  • Epigenetic therapeutics in IBD

    Laboratory research into histone demethylation as a driver of Crohn’s disease inflammation, and its potential as a treatment target.

  • NHS-embedded clinical research

    Implementation-focused studies within everyday NHS practice, such as triage of patients with suspected acute appendicitis.

Patent

Screening Methods for Benign Colorectal Polyps and Colorectal Cancer

UK and international patent · Intellectual Property Office ref. N420839GB · Granted 2024

The patent protects a novel colorectal cancer screening biomarker arising from Mr Eddama’s research.

Research funding

Over £400,000 in research funding secured as Principal Investigator, from charitable and philanthropic funders.

  • 2025Michael Seres Award — EV microRNA biomarkers in Crohn’s diseaseCrohn’s & Colitis in Childhood
  • 2025Postdoctoral fellowship support (24 months)Philanthropic funding
  • 2024Epigenetic modulation in Crohn’s diseaseCrohn’s & Colitis in Childhood
  • 2022Biomarker development for early detection of colorectal cancerUCLH Charity
  • 2021Epigenetic modulation in Crohn’s diseaseCrohn’s & Colitis in Childhood
  • 2020Biomarker discovery in gastrointestinal cancerUCLH Charity
  • 2020PhD funding — thyroid cancer biomarkersEgyptian Bureau
  • 2019Histone demethylation pilot study in IBDCrohn’s & Colitis in Childhood

Selected publications

Selected publications in biomarker and translational research. Mr Eddama has 47 research outputs listed on his UCL profile.

Full publication list(opens in a new tab)

  1. 2026 · Senior & corresponding author

    Use of the Appendistat (APS) score to triage patients with suspected acute appendicitis: a retrospective cross-sectional study in one of the busiest UK surgical emergency units (opens in a new tab)

    International Journal of Surgery · DOI 10.1097/js9.0000000000005433

  2. 2026 · Senior & corresponding author

    Histone H3K27 demethylation drives Crohn’s disease inflammation: GSK-J4 as a potential epigenetic therapy (opens in a new tab)

    Clinical Epigenetics · DOI 10.1186/s13148-026-02165-2

  3. 2026 · Second author

    External validation of the PASO prediction score for primary aldosteronism (opens in a new tab)

    Endocrine Connections · DOI 10.1530/EC-26-0255

  4. 2026 · Second author

    An FDG-first functional imaging approach in phaeochromocytoma and paraganglioma (opens in a new tab)

    Frontiers in Endocrinology · DOI 10.3389/fendo.2026.1833759

  5. 2024 · Corresponding author

    Circulating large extracellular vesicles as diagnostic biomarkers of indeterminate thyroid nodules: multi-platform omics analysis (opens in a new tab)

    BJS Open · DOI 10.1093/bjsopen/zrae139

  6. 2022 · First & corresponding author

    The role of microvesicles as biomarkers in the screening of colorectal neoplasm (opens in a new tab)

    Cancer Medicine · DOI 10.1002/cam4.4664

  7. 2022 · Senior & corresponding author

    Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature (opens in a new tab)

    Clinical Epigenetics · DOI 10.1186/s13148-022-01305-8

  8. 2022 · Senior author

    Circulating microRNAs and clinicopathological findings of papillary thyroid cancer: a systematic review (opens in a new tab)

    In Vivo · DOI 10.21873/invivo.12866

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